What is IONS's five-year median P/E?

There are not enough weekly readings yet for a five-year median P/E.

Does a low historical rank mean a stock is a buy?

No. The rank compares IONS only with its own past. Slower growth or more risk can justify a lower multiple than before. P/E uses earnings and P/S uses revenue from the last twelve months.

Ionis Pharmaceuticals Inc (IONS) P/E ratio history

Health Care

$42.93

Latest weekly close · Market cap $7.1B

As of Oct 24, 2026

IONS has no P/E right now because its earnings over the last twelve months are negative.

No P/E chart for IONS right now

P/E needs positive earnings, so there is no current reading to compare with its history.

See IONS's P/S history

P/E

n/anot ranked

P/E needs positive earnings to be ranked.

Growth, last 12 months vs the year before

Revenue: -7%slowing
EPS: n/a

Price vs revenue and EPS, indexed to 100

Each line starts at 100 at its first positive reading over the last five years. Revenue and EPS change at fiscal quarter ends. EPS was not positive in this window, so it is left out.

PriceRevenue, last 12 months100 = first reading

P/E at each year-end

The last weekly reading of each year, and its percentile against the five years before it.

IONS P/E at each year-end
Year-end	P/E	5-year percentile
Dec 29, 2025	n/a	Too little history
Dec 30, 2024	n/a	Too little history
Dec 25, 2023	n/a	Too little history
Dec 26, 2022	n/a	Too little history
Dec 27, 2021	n/a	Too little history
Dec 28, 2020	117.8×	71
Dec 30, 2019	20.2×	5
Dec 31, 2018	n/a	Too little history
Dec 25, 2017	335.3×	55
Dec 26, 2016	n/a	Too little history

Health Care peers on P/E

Each percentile compares a stock with its own last five years.

Compare IONS with peers

Health Care peers of IONS on P/E
Stock	P/E	Versus its own history	5-year percentile
ABBVAbbVie	80.6×	Above its usual range	76
AMGNAmgen	27.8×	Above its usual range	78
ARWRArrowhead Pharmaceuticals Inc	n/a	Not ranked	n/a, not ranked
BBIOBridgebio Pharma Inc	n/a	Not ranked	n/a, not ranked
BIIBBiogen	44.8×	Historically high	100

Appears in

Sector: Health Care
Screens: Stocks with Low P/E Ratios and Steady Revenue Growth
Stocks Below Their 5-Year Median P/E
Stocks Near Their Lowest P/E Ratios in 5 Years

Screen Health Care stocks the same way

Research on IONS

No articles about IONS yet. How valuation percentiles work

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About this history

What is IONS's current P/E?: IONS has no P/E right now because its earnings over the last twelve months are negative.
What is IONS's five-year median P/E?: There are not enough weekly readings yet for a five-year median P/E.
Does a low historical rank mean a stock is a buy?: No. The rank compares IONS only with its own past. Slower growth or more risk can justify a lower multiple than before. P/E uses earnings and P/S uses revenue from the last twelve months.