What is IONS's five-year median EV/EBITDA?

147.5x. Half of IONS's weekly readings since May 2022 were higher and half were lower. This page has 808 weekly readings, from May 2, 2011 to Oct 19, 2026.

Does a low historical rank mean a stock is a buy?

No. The rank compares IONS only with its own past. Slower growth or more risk can justify a lower multiple than before. P/E uses earnings and P/S uses revenue from the last twelve months.

Ionis Pharmaceuticals Inc (IONS) valuation history

Health Care

$42.93

Latest weekly close · Market cap $7.1B

As of Oct 24, 2026

IONS's EV/EBITDA is unavailable because recent financial data is missing.

No EV/EBITDA chart for IONS right now

IONS has no current EV/EBITDA reading to compare with its history.

See IONS's P/S history

EV/EBITDA

n/anot ranked

No EV/EBITDA rank: recent financial data is missing.

Growth, last 12 months vs the year before

Revenue: -7%slowing
EPS: n/a

Price vs revenue and EPS, indexed to 100

Each line starts at 100 at its first positive reading over the last five years. Revenue and EPS change at fiscal quarter ends. EPS was not positive in this window, so it is left out.

PriceRevenue, last 12 months100 = first reading

EV/EBITDA at each year-end

The last weekly reading of each year, and its percentile against the five years before it.

IONS EV/EBITDA at each year-end
Year-end	EV/EBITDA	5-year percentile
Dec 29, 2025	n/a	Too little history
Dec 30, 2024	n/a	Too little history
Dec 25, 2023	n/a	Too little history
Dec 26, 2022	94.0×	57
Dec 27, 2021	n/a	Too little history
Dec 28, 2020	44.1×	31
Dec 30, 2019	54.2×	2
Dec 31, 2018	n/a	Too little history
Dec 25, 2017	76.5×	1
Dec 26, 2016	n/a	Too little history

Health Care peers on EV/EBITDA

Each percentile compares a stock with its own last five years.

Compare IONS with peers

Health Care peers of IONS on EV/EBITDA
Stock	EV/EBITDA	Versus its own history	5-year percentile
ABBVAbbVie	22.6×	Above its usual range	88
AMGNAmgen	20.3×	Historically high	96
ARWRArrowhead Pharmaceuticals Inc	n/a	Not ranked	n/a, not ranked
BBIOBridgebio Pharma Inc	n/a	Not ranked	n/a, not ranked
BIIBBiogen	20.3×	Historically high	100

Appears in

Sector: Health Care
Screens: Stocks with Low P/E Ratios and Steady Revenue Growth
Stocks Below Their 5-Year Median P/E
Stocks Near Their Lowest P/E Ratios in 5 Years

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Research on IONS

No articles about IONS yet. How valuation percentiles work

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About this history

What is IONS's current EV/EBITDA?: IONS's EV/EBITDA is unavailable because recent financial data is missing.
What is IONS's five-year median EV/EBITDA?: 147.5x. Half of IONS's weekly readings since May 2022 were higher and half were lower. This page has 808 weekly readings, from May 2, 2011 to Oct 19, 2026.
Does a low historical rank mean a stock is a buy?: No. The rank compares IONS only with its own past. Slower growth or more risk can justify a lower multiple than before. P/E uses earnings and P/S uses revenue from the last twelve months.